Nov 7, 2021 · We concluded that (p16-negative) CTCs were correlated with a poor prognosis in patients with head and neck cancer: these findings were similar to those of previous studies [34,35,36,37,38,39,40]. The prognosis of patients with HPV-positive and HPV-negative head and neck cancers, especially oropharyngeal cancers, is notably different [41,42]. Jun 14, 2022 · There were two p16-positive patients among the keratinizing NPCs.The mean circumferential tumor extent scores of 16-positive and p16-negative NPCs were 4.2 and 3.2, respectively with a Nov 6, 2019 · Tonsil cancer is the most common form of oropharyngeal malignancy, and its incidence is sharply rising due to the increasing prevalence of human papillomavirus (HPV)-induced cancers. The presence of HPV can dramatically alter the prognosis of tonsillar cancer, and there have recently been significant changes made to the WHO classification and TNM staging to reflect this. Tonsil cancer can be Apr 14, 2015 · Human papillomavirus (HPV), p16 expression, and TP53 mutations are known prognostic factors in head and neck squamous cell carcinoma, but their role in squamous cell carcinoma of the anal canal Dec 28, 2016 · Tumor p16 status was evaluable in 182 patients with OPC enrolled in the IMCL-9815 study; 41% were p16 positive. When treated with RT alone or RT plus cetuximab, p16-positive patients had a longer OS than p16-negative patients (hazard ratio, 0.40; 95% CI, 0.21 to 0.74 and hazard ratio, 0.16; 95% CI, 0.07 to 0.36, respectively). Jun 25, 2022 · However, in a clinical setting a good external on-slide positive control (e.g. a low-expressor, like tonsil) is common practice and highly recommended to support correct interpretation of cases Sep 28, 2020 · Moreover, a clear association of Kaplan-Meier survival curve of p16-based molecular subtype p16-negative with p16-unknown group supports clustering of RNA-seq based gene expression profiles . As the p16 unknown group consisted of non-oropharyngeal tumors, these results were not surprising as the significance of p16 status in non-oropharyngeal Oct 3, 2018 · Seventy-one percent (98 cases) of cases showed positive p16 expression, whereas 24.8% (34 cases) were negative and 3.6% (5 cases) showed focal positive p16 expression. However, no significant association was found between p16 expression and various clinical and pathologic parameters. Feb 25, 2021 · The expression of p16 is a good surrogate of human papillomavirus (HPV) infection in HPV-associated cancers. The significance of p16 expression, HPV genotype and genera in the outcome of patients with HPV-associated cervical cancer (CC) is unclear. Our aim is to ascertain the prognostic significance of these factors. Data from 348 patients (median age: 47.5 years old) with CC, diagnosed in two Jul 21, 2022 · Comparison of human papilloma virus (HPV) status and p16 in 497 squamous cell carcinomas of different organs revealed HPV in 80.4% of p16 positive and in 20.6% of p16 negative cancers (p<0.0001). It is concluded, that a positive and especially strong p16 immunostaining is a feature for malignancy which may be diagnostically useful in lipomatous znwY3Ny.